A cataplectic attack is sudden in onset and is localized to a specific muscle group or parts of the body. The sudden loss of muscle tone in cataplexy is similar to rapid eye movement (REM)-associated muscle atonia during sleep, but it is occurring during wakefulness. BACKGROUNDĬataplexy is a sudden and transient episode of loss of muscle tone, often triggered by emotions such as laughter, fear, anger, frustration, annoyance, nervousness, embarrassment, and sadness. The present invention relates to a method of treating cataplexy in a subject in need thereof, comprising administering to the subject a therapeutically effective amount of certain carbamate compounds. 13, 2013, the entire contents of which are incorporated by reference herein. You can also report negative side effects to Harmony Biosciences at 1-80.The present invention claims the benefit, under 35 U.S.C. You are encouraged to report negative side effects of prescription drugs to the FDA. The safety and effectiveness of WAKIX have not been established in patients less than 18 years of age. To enroll or obtain information from the registry, call 1-80. You are encouraged to enroll in the WAKIX pregnancy registry if you become pregnant while taking WAKIX. There is a pregnancy exposure registry that monitors pregnancy outcomes in women who are exposed to WAKIX during pregnancy.
Tell your healthcare provider if you are pregnant or planning to become pregnant. You should use an alternative non-hormonal birth control method during treatment with WAKIX and for at least 21 days after discontinuation of treatment. WAKIX can also decrease the effectiveness of some medicines, including hormonal birth control methods. The dosage of WAKIX may need to be adjusted if you are taking these medicines. Some medicines can increase the amount of WAKIX that gets into your blood and some medicines can decrease the amount of WAKIX that gets into your blood. Tell your healthcare provider about all the medicines you take or plan to take, including prescription and over-the-counter medicines. Tell your healthcare provider about any side effect that bothers you or that does not go away. These are not all the possible side effects of WAKIX.
Other side effects included headache, upper respiratory infection, musculoskeletal pain, heart rate increased, and decreased appetite. The most common side effects seen with WAKIX were insomnia, nausea, and anxiety. WAKIX is not recommended in patients with end-stage kidney disease. The risk of QT prolongation may be greater in patients with liver or kidney disease. Tell your healthcare provider about all the other medicines you take. Medicines with this effect can lead to disturbances in heart rhythm, which are more likely in patients with risk factors such as certain heart conditions, or when taken in combination with other medicines that affect QT. WAKIX has an effect on the electrical activity of the heart known as QT/QTc prolongation. Tell your healthcare provider about all your medical conditions, including if you have heart rhythm irregularities, were born with a heart condition, or the levels of electrolytes in your blood are too high or too low. Do not take WAKIX if you are allergic to pitolisant or any ingredient in WAKIX, or if you have severe liver disease.
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